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Scientific Studies

Brain Health

Neuroprotective Effects of Molecular Hydrogen: A Critical Review

Chen W, Zhang HT, Qin SC. Neuroprotective Effects of Molecular Hydrogen: A Critical Review. Neurosci Bull. 2021 Mar;37(3):389-404. doi: 10.1007/s12264-020-00597-1. Epub 2020 Oct 20. PMID: 33078374; PMCID: PMC7954968.

Hydrogen-rich water and caffeine for alertness and brain metabolism in sleep-deprived habitual coffee drinkers

Yunbo Xie, Guohua Song, The Clinical Use of Hydrogen as a Medical Treatment, Molecular Hydrogen in Health and Disease, 10.1007/978-3-031-47375-3_6, (93-111), (2024).

Molecular hydrogen therapy for neurological diseases: a review of current evidence

Ramanathan, Dinesh, et al. “Molecular Hydrogen Therapy for Neurological Diseases: A Review of Current Evidence.” Medical Gas Research, vol. 13, no. 3, Dec. 2022, pp. 94–98. PubMed Central, https://doi.org/10.4103/2045-9912.359677.

Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota

Lin, Yi-Tong, et al. “Hydrogen-Rich Water Ameliorates Neuropathological Impairments in a Mouse Model of Alzheimer’s Disease through Reducing Neuroinflammation and Modulating Intestinal Microbiota.” Neural Regeneration Research, vol. 17, no. 2, Feb. 2022, p. 409. journals.lww.com, https://doi.org/10.4103/1673-5374.317992.

Inhaled molecular hydrogen reduces hippocampal neuroinflammation, glial reactivity and ameliorates memory impairment during systemic inflammation

de Deus, Júnia Lara, et al. “Inhaled Molecular Hydrogen Reduces Hippocampal Neuroinflammation, Glial Reactivity and Ameliorates Memory Impairment during Systemic Inflammation.” Brain, Behavior, & Immunity - Health, vol. 31, Aug. 2023, p. 100654. ScienceDirect, https://doi.org/10.1016/j.bbih.2023.100654.

Hydrogen-Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects in an Acute Ischemia-Reperfusion Injury Mouse Model

Lee, Dain, and Jong-Il Choi. “Hydrogen-Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects in an Acute Ischemia-Reperfusion Injury Mouse Model.” BioMed Research International, vol. 2021, no. 1, 2021, p. 9956938. Wiley Online Library, https://doi.org/10.1155/2021/9956938.

The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges

He, Jiaxuan, et al. “The Role of Hydrogen Therapy in Alzheimer’s Disease Management: Insights into Mechanisms, Administration Routes, and Future Challenges.” Biomedicine & Pharmacotherapy, vol. 168, Dec. 2023, p. 115807. ScienceDirect, https://doi.org/10.1016/j.biopha.2023.115807.

Transcriptomic and metabolomic studies on the protective effect of molecular hydrogen against nuclear electromagnetic pulse-induced brain damage

Ma, Long, et al. “Transcriptomic and Metabolomic Studies on the Protective Effect of Molecular Hydrogen against Nuclear Electromagnetic Pulse-Induced Brain Damage.” Frontiers in Public Health, vol. 11, Feb. 2023. Frontiers, https://doi.org/10.3389/fpubh.2023.1103022.

Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice

Nagata, Kazufumi, et al. “Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice.” Neuropsychopharmacology, vol. 34, no. 2, Jan. 2009, pp. 501–08. www.nature.com, https://doi.org/10.1038/npp.2008.95.

Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia

Ghanizadeh, Ahmad, and Michael Berk. “Molecular Hydrogen: An Overview of Its Neurobiological Effects and Therapeutic Potential for Bipolar Disorder and Schizophrenia.” Medical Gas Research, vol. 3, no. 1, June 2013, p. 11. BioMed Central, https://doi.org/10.1186/2045-9912-3-11.

Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection

Ono, Hirohisa, et al. “Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection.” Journal of Stroke and Cerebrovascular Diseases: The Official Journal of National Stroke Association, vol. 26, no. 11, Nov. 2017, pp. 2587–94. PubMed, https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.06.012.

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